Archive for ovarian cancer

FREE Running Program for Cancer Survivors in MD, DC, VA, NY & Chicago

Andy & Alan 2004 Bay Bridge 10K

Andy & Alan @ Rockville Rotary Twilighter 8K Runfest 1992

 

Pictured above is my husband Alan (on the right) with his childhood friend Andy.  Since this picture was taken, Andy has run more than 30 marathons, completed 13 triathlons and has become a certified running coach.  Despite all these accomplishments, Andy always made time to go for a run or walk with Alan, even after he was diagnosed with cancer.

 

It was no surprise to me that Andy connected with The Ulman Cancer Fund’s CANCER to 5K Training Program - a FREE 12-week training program designed to introduce or reintroduce cancer survivors to training for and completing a 5K road race.  Amazing, right?!

ABOUT The CANCER to 5K Training Program:

Research has now shown that exercise is especially important for cancer survivors both in and out of active treatment.  Regular exercise not only improves mood, boosts self-confidence and reduces fatigue, but there is loads of evidence suggesting that higher levels of physical activity can help keep the cancer from recurring.

 

The Cancer to 5K Training Program is a progressive run/walk program designed to get cancer survivors to the 5K finish-line happy, healthy and injury-free.  

*  Who can join?  Cancer to 5K is open to any cancer survivor regardless of age, location, treatment status or fitness level.  Survivors who have completed treatment as well as survivors who are currently undergoing treatment can participate.

*  Where is training held?  If you live in the following areas, certified running coaches and experienced volunteer runners (aka “Sherpas”) will help train you in a small group setting.  Each 12-week session is limited to 10 participants.  Click HERE for exact locations in:

      • Washington DC/Northern Virginia
      • Montgomery County Maryland
      • Howard County, Maryland
      • Baltimore, Maryland
      • New York, NY
      • Chicago, IL.

* What if you live elsewhere?  If you live outside the current group training areas, you can still participate with The CANCER to 5K “At Home” Training Program.  As a Cancer to 5K “At Home” participant, you will receive one-on-one coaching with a Cancer to 5K coach. Workouts will be sent to you via email, and you will have access to your coach via email and phone.

Registration for the fall training season is now OPEN!  
Group workouts will begin in August 2014.
“At-Home” participants can begin training anytime.

 

For more information, contact Program Manager Laura Scruggs via email at laura@ulmanfund.org  or via 410.964.0202 x108.  

Please note:  A medical waiver must be signed by the participant’s current primary care physician to ensure that training for a 5K won’t negatively impact treatment or recovery.

 

Financial Assistance from Walk In My Shoes Cancer Foundation

 

 

If you’ve been diagnosed with cancer and are having a hard time making ends meet, check out the Walk In My Shoes Foundation.

Walk In My Shoes Foundation assists cancer patients with paying rent, mortgages, utility bills, medication, purchasing gas cards, buying groceries, etc.  To qualify for assistance, which is based on availability, the following guidelines have been set:

  • Only patients undergoing cancer treatment are eligible for assistance.
  • Only bills in patient’s name are eligible for payment.
  • Maximum assistance is $500.00 per patient per calendar year.
  • First come first serve basis.
  • No income guidelines.
  • Men, women, children are welcome to apply regardless of type of cancer.
  • Cash will not be disbursed.

To apply, please complete the form on the Walk In My Shoes Foundation CONTACT US page or email them directly at info@walkinmyshoesfoundation.com.  Someone should contact you within 48 hours.

Personalizing YOUR Cancer Treatment (part 4): Do you know your cancer biomarkers?

Personalized-Medicine

In the near future, instead of saying, “I have breast cancer,” a patient will say something like , “I have a HER2-positive carcinoma with a KRAS mutation.”  Cancer will be defined by it’s own unique molecular profile and biomarkers rather than the body part where it originated.

To learn more about the dozens of biomarkers already being used to guide cancer treatment, check out the table below. Please note: there are thousands of known biomarkers without currently known effectiveness or relevance to cancer care. This table only represents the biomarkers that are currently known to be significant in informing cancer care today.*

Biomarker About Cancers that may benefit from testing Treatments associated with response or lack of response/resistance*
ALK anaplastic lymphoma kinase, an enzyme that can form a oncogenic fusion gene with EML4 lung (non-small cell), lymphoma (anaplastic large-cell), nervous system (familial neuroblastoma) crizotinib (Xalkori®), pemetrexed (Alimta®)
AR androgen receptor, part of the nuclear hormone receptor superfamily, active in cell signaling and therefore cell multiplication and growth prostate, breast, ovarian, bladder, lung (non-small cell) bicalutamide (Casodex®), flutamide (Eulexin®), goserelin (Zoladex®), leuprolide (Lupron®), abarelix (Plenaxis®), gonadorelin (Factrel®)
BRAF also know as v-raf murine sarcoma viral oncogene homolog B1, a proto-oncogene in the RAF/MIL family of molecules active in MAP/ERK cell signaling, promotes cell multiplication and growth colon, skin (melanoma), lung (adenocarcinoma), thyroid (papillary thyroid carcinoma), nervous system (pleomorphic xanthoastrocytomas with and without anaplasia) cetuximab (Erbitux®), panitumumab (Vectibix®), vemurafenib (Zelboraf®)
BRCA1 a so-called “breast cancer gene”, its expression in many cancers can indicate potential response to certain types of therapies lung, ovarian cisplatin (Platinol®)
c-Kit cytokine receptor also know as CD117, a proto-oncogene that interacts with cell growth factors, plays a roll in cell survival, multiplication and differentiation GIST (gastrointestinal stromal tumor), skin (melanoma), blood (acute myelogenous leukemia) imatinib (Gleevec®), sorafenib (Nexavar®), sunitinib (Sutent®)
c-MET also known as MET (mesenchymal epithelial transition factor) or HGFR (hepatocyte growth factor receptor), a proto-oncogene active in cell signaling, promotes cancer cell growth and multiplication lung (non-small cell), ovarian erlotinib (Tarceva®), gefitinib (Iressa®)
COX-2 cyclooxygenase-2, also known as protaglandin-endoperoxide synthase-2 (PTGS2), an enzyme important to creation of prostaglandins, which are messenger molecules that play a role in many cancers lung (non-small cell) celecoxib (Celebrex®)
EGFR epidermal growth factor receptor, also known as ErbB-1 or HER1, a receptor tyrosine kinase active in cell signaling, promotes cell growth and multiplication lung (non-small cell) cetuximab (Erbitux®), erlotinib (Tarceva®), gefitinib (Iressa®), panitumumab (Vectibix®)
EGFR secondary mutation (T790 M) a mutation of the EGFR gene associated with acquired resistance to certain treatments lung (non-small cell), colorectal, head and neck resistance to erlotinib (Tarceva®), gefitinib (Iressa®)
ER estrogen receptor, part of the nuclear hormone family of intracellular receptors, active in cell multiplication breast, ovarian, female genital tract cancer anastrazole (Arimidex®), exemestane (Aromasin®), letrozole (Femara®), tamoxifen (Nolvadex®), megestrol acetate (Megace®, Megace® ES), fulvestrant (Faslodex®), toremifene (Fareston®), medroxyprogesterone, (Provera®, Amen®, Curretab®, Cycrin®), goserelin (Zoladex®), leuprolide (Eligard®, Lupron®, Viadur®)
ERCC1 excision repair cross-complementation group 1, an enzyme active in DNA repair and therefore a sign of resistance to treatments that work by disrupting tumor DNA lung (non-small cell and small cell), gastric, ovarian, colorectal, bladder resistance to cisplatin (Platinol®), carboplatin (Paraplatin®), oxaliplatin (Eloxatin®)
HER2 human epidermal growth factor receptor 2, also known as HER2/neu or ErbB-2, a receptor tyrosine kinase active in cell signaling, promotes cell growth and multiplication breast, gastroesophageal, gastric, ovarian, colorectal lapatinib (Tykerb®), trastuzumab (Herceptin®), doxorubicin (Adriamycin®, Rubex®), liposomal doxorubicin (Caelyx®, Myocet®), epirubicin (Ellence®)
KRAS proto-oncogene of the Kirsten murine sarcoma virus, active in cell signaling in the EGFR pathway, promotes cell growth and multiplication lung (non-small cell), colon, pancreatic cetuximab (Erbitux®), erlotinib (Tarceva®), gefitinib (Iressa®), panitumumab (Vectibix®)
MGMT O-6-methylguanine-DNA methyltransferase is a gene that encodes a DNA repair enzyme, loss of MGMT may play a role in cancer formation, MGMT can also interfere with treatments that work by disrupting tumor DNA breast, lung (non-small cell), esophageal, brain (glioblastoma multiforme, oligodendrogliomas), skin (melanoma), pituitary gland (carcinoma) lack of response to temozolomide (Temodar®)
MRP1 multidrug resistance-associated protein 1, an ATP-dependent transmembrane drug efflux pump associated with resistance to many drugs breast, lymphoma, head and neck lack of response to anthracyclines such as doxorubicin (Adrimycin®), vinca alkaloids, and methotrexate (Trexall®)
PGP p-glycoprotein, also known as P-gp, an ATP-dependent transmembrane drug efflux pump associated with acquired resistance to many drugs breast, ovarian, lymphoma, head and neck lack of response to anthracylines such as doxorubicin (Adriamycin®), epirubicin (Ellence®) and liposomal-doxorubicin (Doxil®), and other drugs such as paclitaxel (Taxol®), docetaxel (Taxotere®), vinblastine (Velban®), vincristine (Oncovin®), vinorelbine (Navelbine®)
PIK3CA a specific mutation within the PI3 (phosphoinositide 3) kinase pathway or a gene copy number variation, aberrations along the PI3K pathway are associated with many cancers colorectal, brain (glioblastoma), gastric, breast, lung, ovarian lapatinib (Tykerb®); resistance to cetuximab (Erbitux®), panitumumab (Vectibix); decreased response to trastuzumab (Herceptin®)
PR progesterone receptor, also called PGR, part of the nuclear hormone family of intracellular receptors, active in cell multiplication breast, ovarian, female genital tract cancer letrozole (Femara®), tamoxifen (Nolvadex®), fulvestrant (Faslodex®), toremifene (Fareston®), exemestane (Aromasin®), anastrozole (Arimidex®), goserelin (Zoladex®), gonadorelin (Factrel®), leuprolide (Eligard®, Lupron®, Viadur®), medroxyprogesterone (Provera®, Amen®, Curretab®, Cycrin®), megestrol acetate (Megace®, Megace® ES)
PTEN phosphatase and tensin homolog, a tumor suppressor active in EGFR, HER2 and AKT cell signaling pathways breast, colon, lung (non-small cell), brain (glioblastoma), head and neck low expression associated with lack of response to cetuximab (Erbitux®), gefitinib (Iressa®), trastuzumab (Herceptin®), panitumumab (Vectibix®), erlotinib (Tarceva®)
RRM1 ribonucleotide reductase subunit M1, an enzyme required for DNA synthesis from RNA and therefore can interfere with treatments that work by disrupting RNA activity lung (non-small cell), pancreatic high expression associated with lack of response to gemcitabine (Gemzar®), hydroxyurea (Hydrea®, Droxia®)
SPARC secreted protein acidic rich in cysteine, a protein active in tumor growth and spreading skin (melanoma), breast, gastric, pancreatic, head and neck albumin-bound paclitaxel/nab-paclitaxel (Abraxane®)
TLE3 a member of the transducin-like enhancer of split family of proteins, implicated in creation of tumors breast, ovarian taxane therapy such as paclitaxel (Taxol®), docetaxel (Taxotere ®)
TOPO2A topoisomerase IIA, an enzyme active in DNA synthesis and repair breast, colon, ovarian, lung (small cell) doxorubicin (Adriamycin®), epirubicin (Ellence®, Pharmorubucin®), liposomal doxorubicin (Caelyx®, Myocet®)
TS thymidylate synthetase, an enzyme active in DNA synthesis and repair, can be inhibited by certain compounds breast, colon, gastric, head and neck, liver, pancreatic, lung (non-small cell) lack of response to 5-fluorouracil (Adrucil®), cytarabine (Cytosar-U®), pemetrexed (Alimta®)
TUBB3 Class III -tubulin, protein found in microtubules which are important cell structures ovarian, lung (non-small cell) taxanes such as paclitaxel (Taxol®), docetaxel (Taxotere ®), vinca alkaloids such as vinorelbine (Navelbine®)

* Biomarker status (overexpressed, underexpressed, positive or negative for specific mutations, etc.) determines whether that biomarker is associated with response, lack of response or resistance to each treatment. Treatment associations are from published, peer-reviewed medical literature. Citations available upon request. Only your doctor can decide which treatments are appropriate for you.

**Got questions about YOUR biomarkers, e-mail PatientNavigator@carisls.com.  A Patient Navigator who is well versed in molecular profiling and biomarkers will answer your questions.  (this is a FREE service provided by Caris Life Sciences.) 

*** Source:  MyCancer.com (an educational resource sponsored by Caris Life Sciences®) is a fantastic website for cancer patients and their caregivers that provides information about personalizing your cancer treatment using molecular profiling and cancer biomarkers.

Applying for Social Security Disability Benefits with Cancer

 

Meet GUEST BLOGGER Ram Meyyappan. Ram is the senior editor and manager of the Social Security Disability Help website.  Social Security Disability Help contains information on how to apply for disability with over 400 conditions, helpful tips, FAQs along with an extensive disability glossary.

 

If you are a parent suffering from any type of cancer, the condition or the effects of the treatments you are undergoing may make it difficult to take care of your kids, let alone returning to work. In such cases, financial assistance may be available through one of the two Social Security Disability programs. There are two disability programs available to those who qualify under the SSA’s disability criteria. These include the SSI (Supplemental Security Income) program and the SSDI (Social Security Disability Insurance) program.

SSI

SSI is a needs-based program. In order to be eligible, you must be deemed disabled by the Social Security Administration and you must meet certain financial criteria. As of 2013, to qualify for SSI, you must not earn more than $710 as an individual or $1,060 as a couple. You must also not have assets that exceed $2,000 as an individual or $3,000 as a couple.

SSDI

Unlike SSI, SSDI is not a needs-based program. There are no financial criteria to meet. You must, however, have earned enough work credits through your previous work history. In order to have enough work credits to qualify for SSDI, you must have worked five of the past ten years. If you are not old enough to have worked five of the past ten years, you need to have worked half of the time you were able to do so.

Cancer and Meeting the Medical Requirements

The SSA uses a manual called “the blue book” to evaluate whether or not a condition qualifies for disability benefits. Cancer is covered in Section 13 of the SSA’s blue book under Malignant Neoplastic Diseases. Just being diagnosed with cancer alone does not mean that you will qualify for benefits unless it is a type of cancer that is listed in the compassionate allowances program. In most cases, the cancer has to be inoperable, have distant metastases (has spread), or be recurrent after surgical procedures or irradiation.

You will need to prove through your medical records and work history that your cancer prevents you from working at the job at which you were previously working or any other job for which you are qualified.

Qualifying Under the Compassionate Allowances Program

Certain types of cancer can qualify for Social Security Disability benefits in less than two weeks under the SSA’s Compassionate Allowances program. Under this program, individuals who are suffering from very severe conditions can bypass the standard disability claim process and be approved for benefits a lot faster. You will need a physician’s opinion stating that the cancer is not operable or an operative note stating that the cancer was not completely resected in order to qualify under this program. If an operative note is not available, a pathology report indicating positive margins can be used. When applying for benefits, make sure you include this medical documentation and make it clear how you qualify for benefits under the Compassionate Allowances guidelines.

There are numerous cancers that are listed in the compassionate allowance program. For a complete list of all compassionate allowances conditions, please visit: http://www.disability-benefits-help.org/compassionate-allowances.

How to Apply for Social Security Disability Benefits

You can apply for Social Security Disability benefits online or in person at your local Social Security office. Make sure that you have all of the medical evidence that you will need at the time of your application. While the SSA will have you fill out forms that allow them to request copies of your medical records, it is always best to submit medical records on your own as a part of your application to ensure that the SSA receives complete documentation that supports your disability claim.

FREE Kit to Help Manage Side Effects from Chemotherapy

A sample of an Adult Comfort Kit

A sample of an Adult Comfort Kit

We all need a little love once in a while… and if you’ve been diagnosed with cancer and are receiving chemotherapy, you deserve a little extra lovin’. That’s what Peppermint & Ginger Comfort Kits are all about…

 

Peppermint & Ginger Comfort Kits are FREE kits created to help provide comfort and help alleviate some of the more common side effects caused by chemotherapy.  An “Adult Kit” contains peppermint and ginger teas (which can help ease nausea), a soft bristle toothbrush, alcohol free mouth wash and toothpaste and lip balm (to help ease oral side effects experienced as a result of treatment), warm socks and a relaxation CD.  When possible, P&G adds in other goodies as well.  Their “Pediatric Kit” contains hot chocolate instead of teas and it’s contents will vary depending on the age of the patient.

 

If you know of a cancer patient receiving chemotherapy or if you yourself are a patient and would like one of these comforting kits, please click HERE to request one.

FREE Wigs for Cancer Patients Living in Des Moines, Iowa

 

If you live in Des Moines, Iowa and have lost your hair as a result of cancer treatments, check out Strands of Strength.  Strands of Strength provides FREE quality wigs to cancer patients- men, women or children- regardless of age or type of cancer – who live in Des Moines, Iowa and who could not otherwise afford a wig.

 

Here’s the dealio (as my daughter always says)…  

Strands of Strength works closely with medical professionals at Iowa HealthBlank Children’s Hospital and Mercy Hospital.   These hospitals will provide patients in need a voucher slip for a free wig.  

Patients can then choose any wig they like from any Strands of Strength-approved wig shop.  The voucher represents payment to the shop.  It’s as simple as that.

For more information, visit StrandsofStrength.com or contact Deb at deb@strandsofstrength.com or via phone at (515) 240-5843.

 

Immunotherapy Clinical Trial Finder

cancer-and-immune-system1

 

Immunotherapy is a type of cancer treatment that boosts the immune system’s fighting defenses to help the body destroy cancer cells.  Many clinical trials testing new and potentially promising “immunotherapies” are currently enrolling cancer patients in the United States and abroad.  To learn more about immunotherapy clinical trials or to find a trial that might be right for you, check out The Cancer Research Institute’s Clinical Trial Finder.  Here’s how it works:

 

  1. Select a cancer type.*
  2. Fill out CRI’s simple request form.
  3. Within 3 business days, you will be emailed a list of trials that you may be eligible for.
  4. Take the results to your doctor to discuss; contact the clinical trial sites/research teams directly; and/or contact the Clinical Trial Institute at clinicaltrials@cancerresearch.org for more information or for help interpreting your results.

* Current cancer types include:  Brain CancerBreast CancerCervical and HPV-Related CancersColorectal CancerLeukemiaLiver CancerLung CancerLymphomaMelanomaMyelomaOvarian CancerPancreatic CancerProstate CancerSarcoma and Bone CancersStomach Cancer.

If your cancer type is not listed, send an email to clinicaltrials@cancerresearch.org with information about your cancer type, stage and treatment history, as well as your location.  They see if there are any matches.

FREE High Quality Wigs for Female Cancer Patients

Cancer patients say that hair loss is one of the most emotionally devastating side effects of chemotherapy.  To help maintain a positive body image & sense of normalcy, many cancer patients opt to wear a wig.  However, some insurance companies won’t cover the cost of a wig, and the ones that do typically don’t provide enough funds to make purchasing a good quality wig an option.

Check out Lolly’s Locks… they provide high-quality wigs (made from human hair) to female cancer patients who cannot otherwise afford them.

 

Here’s the dealio (as my daughter always says)

To apply for a FREE wig, fill out an application (click HERE).  All applications must be submitted with proof of medical diagnosis.  Applications are approved on a case by case basis.

To qualify for a wig from Lolly’s Locks:

  • You must be a female cancer patient undergoing chemotherapy, and suffering from hair loss as a result of treatments.
  • Patients can be diagnosed with any type of cancer but must be over the age of 18 years old.
  • You must reside in the USA.

Once approved, you can actually order the wig from the privacy of your own home.  A detailed order form (how you want the wig parted; straight hair, curly, medium wave, etc; hair length; % of hair highlighted; measurements for cap size; etc) will be emailed to you.  You will also have a follow-up phone conversation with Lolly’s Locks wig distributor as well as a wig stylist.  Once these conversations are completed, you should receive your wig in two weeks.

 

 

For Pregnant Women Who Find Out They Have Cancer

Image credit: 123RF Stock Photo

 

Cancer doesn’t discriminate.  It doesn’t care if you are young or old, a good person or a mean one.  Cancer doesn’t care where you live or how much money you earn or what values & religious beliefs you hold.  And cancer doesn’t care if you are in the midst of bringing another life into the world either.  Yes, it’s true… pregnant women can be diagnosed with cancer just like anyone else.

 

Currently, cancer during pregnancy occurs in approximately one out of every 1,000 pregnancies.   And as more women delay childbirth until they’re older, the incidence of cancer during pregnancy, particularly breast cancer, is rising.  In the meantime, few oncologists or obstetricians treat more than 2 or 3 patients in this situation in an entire career and little research exists to help guide patients and their doctors on different treatment options.  So where can someone turn to get answers to questions about being treated for cancer during pregnancy…

 

Hope for Two is an organization dedicated to connecting woman who are pregnant with cancer to other women who have been pregnant with the same type of cancer.  Check out the “Survivor Stories” section of their website… it’s AMAZING!

 

The Cancer and Pregnancy Registry, which was created by and is currently maintained by Dr. Elyce Cardonick, collects information about the diagnosis, and treatment of cancer in pregnant women. With each patient’s permission, Dr. Cardonick reviews their cancer treatment and pregnancy outcomes. What is unique about this database is that the children are not only followed up until birth, but on an ongoing yearly basis. Pregnant women diagnosed with cancer find the registry helpful in learning how many other pregnant women were diagnosed and treated for the same cancer during pregnancy. Patient data is kept confidential.

Dr. Elyce Cardonick is also a Maternal Fetal Medicine specialist at Cooper University Hospital in New Jersey and is available to offer guidance to women and/or their physicians. She can work with your oncologist in deciding which tests and procedures can be performed, and when, during pregnancy to maximize the safety of the fetus while not compromising the chance of cure of the mother.

To reach Dr. Cardonick or to learn more about The Cancer and Pregnancy Registry, visit www.cancerandpregnancy.com or call 1-877-635-4499 (toll free).  A message may also be left on Dr. Cardonick’s private voicemail at 1-856-757-7876.

If you know of other good resources to help women who are pregnant and also have cancer, please jot them down as a comment on this blog… Knowledge is power, please share the power… 

 

WTF is “Ovarian Tissue Cryopreservation”?

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For younger women diagnosed with cancer, the same treatments that are designed to save their lives can damage their ovaries and render them infertile.  However, there are options available to help preserve fertility.

 

For some female patients, egg & embryo freezing is one option if done before treatment begins.  For other women with aggressive cancers or hormone-sensitive cancers, this is not an option.  Women with aggressive cancers may need to start treatment immediately and don’t have the 3-6 weeks needed to harvest eggs.  Women with a hormone-sensitive cancer can not have their ovaries stimulated as this process can exacerbate the cancer.

 

For these women (those who can not harvest & freeze their eggs), there is an experimental option called “Ovarian Cryopreservation.”  Dr. Kutluk Oktay, director of the Institute for Fertility Preservation/Reproductive Specialists of New York explains it like this… “Ovarian cryopreservation is a procedure where, when a woman is faced with a medical condition that would affect [her] future fertility, the ovary is removed through a keyhole procedure and it’s taken through a specialized process which involves treating the tissue with antifreeze substances and utilizing an automated process to preserve the ovary for future use.”

 

How does this new ovary-freezing procedure work?

According to Dr. Oktay, doctors first remove the ovary and then, once a woman has completed cancer treatment, transplant the tissue back into the abdomen – or even under the skin. Once transplanted, the ovarian tissue will be able to turn its supply of immature eggs into viable ones.  The procedure takes about 40 minutes and can be done under local anesthesia.

 

Ovarian Tissue Cryopreservation is not recommended for young women with ovarian cancer, leukemias or lymphoma.  This process also potentially lends itself putting cancer-tainted tissue back into a patient who’s been cured.

 

Got more questions?  Connect with Fertile Hope - they help cancer patients get the information they need to make educated fertility decisions before and after cancer treatments- from understanding fertility risks to fertility preservation techniques to understanding what parenthood options exist after cancer.  (Fertile Hope is a national LIVESTRONG initiative)