Archive for TYPE OF CANCER

The 411 on Cancer Immunotherapy

 

One of the most promising areas in cancer research and precision medicine today is “Immunotherapy.  Credited as the first therapy ever proven to extend the lives of patients with metastatic melanoma, immunotherapy is changing the way some cancers are treated.

 

Here’s the dealio (as my daughter always says)…  Immunotherapy refers to a class of treatments that use the body’s own immune system to help fight cancer.  Some treatments boost the body’s immune system in a very general way, while others help train the immune system to attack cancer cells specifically.  Today, most people who receive immunotherapy have cancers that are advanced. Their cancers have either recurred and spread after primary treatment, or were diagnosed in an advanced stage.  Often times, patients receiving immunotherapy treatments are enrolled in a clinical trial.

 

Because immunotherapy is a rapidly evolving field, understanding the “basics”  can be complicated and confusing.  One of the best resources I’ve found to help explain the complexities of immunotherapy is the Cancer Support Community’s  new program… Frankly Speaking About Cancer: Your Immune System & Cancer Treatment.  

 

Additionally, the Cancer Support Community is hosting several FREE webinars on immunotherapy for patients diagnosed with melanoma, leukemia, lymphoma and lung cancers.  “Immunotherapy Advances in Melanoma” is scheduled for September 9, 2014 at 6:30pm EST.

 

Other fantastic resources on immunotherapy include:

Cancer Research Institute

The Cancer Research Institute (CRI) is dedicated to advancing the immune system’s power to conquer all cancers. Click HERE to see brief statistics on specific cancers as well as an overview of the current and potential impact of immunotherapy for each cancer type. All content on this site has been reviewed and verified by experts in cancer immunotherapy.

 

TheAnswerToCancer.org

Great informational site for patients and caregivers who are interested in learning more about cancer immunotherapy as a treatment option.  Hear firsthand from patients who have benefitted from this novel approach to cancer treatment.  

 

Immunotherapy Clinical Trial Finder  

Many patients are not aware of opportunities to participate in clinical trials and may find it difficult to identify trials that may be appropriate for them.  The Cancer Research Institute has partnered with EmergingMed to provide the Cancer Immunotherapy Clinical Trial Finder, a tool designed to help patients quickly search for clinical trials that match their specific cancer diagnosis and treatment history.  

The Cancer Research Institute also has Clinical Trial Navigators available Monday through Friday from 8:30 a.m. to 6:00 p.m. EST who can help you find personalized trial matches, connect with study sites, and answer many of your questions.  Simply call (toll-free) 1-855-216-0127.  This service is free and completely confidential.  

 

Lazarex Cancer Foundation  

If you need help navigating clinical trial options or financial assistance to attend a clinical trial, connect with Lazarex Cancer Foundation.  Lazarex can help with the costs associated with participating in a clinical trial, including:

  • Transportation (airfare, gas, rental cars, taxi fare, parking/tolls)
  • Lodging (short- and long-term housing)
  • Certain medical expenses not covered by insurance and necessary for clinical trial treatment.

 

A Brief History of Immunotherapy

In case you’re interested, Targeted Oncology (fantastic site for the latest news and insights from leading researchers and cancer centers) has a great article on the history of immunotherapy which dates back to the late 19th century.

 

Make sure to discuss any findings with your doctors and health care team.  Knowledge is power…

 

What You Need to Know About Breast Reconstruction

The Cancer Support Community surveyed 762 breast cancer survivors (who were eligible for breast reconstruction) and found that 43% of these women did not receive any info about breast reconstruction PRIOR to making surgical decisions (mastectomy or lumpectomy). Why is this a huge problem? Well, if you opt to reconstruct one or both boobs, the method you choose to reconstruct can be affected depending on how the initial surgery is done. Since you can’t go back and re-do your mastectomy, this is an extremely important conversation to have with your doctor BEFORE a mastectomy takes place.

 

Watch this fantastic video created by Understand.com to learn more about breast reconstruction options.  Then ask your doctor what options would be best for you.

Fight Cancer & WIN! With This Kick-Ass Cancer Fighting Video Game

 

Any oncologist or parent will tell you that getting young cancer patients (that includes children, teenagers and even young adults) to stick to their treatment regimens and take their medications when and how they have been prescribed is no easy task.  To help encourage treatment adherence (which improves outcomes and saves lives!), researchers at HopeLab created  Re-Mission2, a series of six very cool, FREE video games that are super fun to play, a tad bit addicting ;-) AND help it’s players beat a diagnosis of cancer.  

 

Here’s how it works:  

Re-Mission2 gives players a better understanding of their disease and how their bodies benefit from treatments that can be inconvenient, unpleasant or even debilitating at times. Research studies have shown these games not only encourage treatment adherence, but they also give players a much needed sense of power and control*.

 

Each game puts players inside the human body to fight cancer with an arsenal of weapons and super-powers, like chemotherapy, radiation, targeted cancer drugs, antibiotics and the body’s natural defenses. The game play parallels real-world strategies used to successfully destroy cancer and win.  A-M-A-Z-I-N-G!

Download Re-Mission2 Today for FREE!

Simply click HERE to access all six Re-Mission2 games online or download Nanobot’s Revenge mobile app from iTunes  or Google Play.  And let the games begin!

 
 
P.S.  Major kudos to Cigna Healthcare and the Childhood Leukemia Foundation Keeping Kids Connected  program for providing free iPads preloaded with  Re-Mission 2: Nanobot’s Revenge  to hospital centers throughout the country. 
 
*For more information on the above mentioned research studies, see
Hope Lab Research: Re-Mission Outcomes Study and Re-Mission Attitude Studies in the Brain

Protect Yourself From Mesothelioma (aka Summer’s Silent Threat)

asbestos1

 

Meet PATIENT ADVOCATE Susan Vento of The Asbestos Cancer Victims’ Rights Campaign (ACVRC) a national campaign dedicated to protecting the rights of asbestos victims, making sure they and their families are protected in seeking compensation, and opposing legislation that seeks to roll back their rights.  At the end of this article written by the ACVRC, I’ve listed some incredible resources to help anyone touched by mesothelioma, the cancer caused by asbestos exposure.  

 

“Now that summer is in full swing, people are jumping into their long-awaited plans, projects, and warm weather activities. Though this season is characteristically carefree, there is great risk of coming into contact with invisible carcinogenic hazards, asbestos specifically, that can severely compromise your long-term health.

As a result of the widespread and historical use of asbestos, many common summer hobbies and recreational activities come with an unforeseen risk of exposure. According to the World Health Organization, more than 107,000 people die each year from asbestos-related diseases. Before you embark on any of the following summer activities, your awareness of how you could potentially expose yourself to asbestos is crucial.

DIY & DEMOLITION

Summer is the season when homeowners often decide to dust off their do-it-yourself gloves. Roughly three quarters of homeowners are planning to work on home improvement projects this year, and according to the EPA, over 35 million homes in the U.S. contain asbestos, making any of these projects potentially dangerous.

Within the home, asbestos may be found in places like attic and wall insulation, vinyl flooring, hot water pipes, and textured paint on walls and ceilings. When asbestos-containing materials are disturbed or damaged, the microscopic fibers become airborne which can then be inhaled into the lungs, causing disease. If you drill, cut, saw, hammer, or move anything in your home that may contain asbestos without proper inspection, you’re putting you and your loved ones at great risk.

EXPLORING ABANDONED BUILDINGS

In the summer, children are known to explore abandoned or demolished properties including buildings, railroad tracks, factories, and vehicles. If your child rummages through these neglected and unregulated areas, they will be at great risk for coming into contact with and disturbing asbestos-laden materials, breathing in its lethal dust. Take the time to sit with your kids and educate them about these hidden dangers, while also providing suggestions for fun alternative adventures.

GARAGE SALES & ANTIQUING

In addition to the building materials already discussed, many household items and appliances were commonly manufactured with asbestos prior to the early 1980s. When on the hunt for garage sales, flea markets, and antique shops, avoid purchasing vintage-looking commodities such as heat-resistant fabrics, auto parts, and stove top ovens. There are even oven mitts, irons, and ironing boards that were once marketed specifically because they were made with asbestos. Consult a “Safe Antiques” guide before your next excursion to ensure you won’t mistakenly invite anything made with asbestos into your home.

GARDENING

As a result of geological processes, naturally occurring asbestos (NOA) can be found in soil and rock which can then be disturbed by natural weathering and human activity. When digging and tilling gardens in areas potentially containing NOA, asbestos mineral fibers can be released into the air and inhaled, or tracked into the home on clothing and shoes. To locate NOA areas and ensure your gardening project is a safe endeavor, start by consulting the U.S. Geological Survey reports and contact a state geologist.

CAMPING & BONFIRES

Many people use camp and bonfires for discarding old cabin or household scraps, or they simply enjoy finding nearby, useless materials to burn. However, what you may not realize is that the materials you choose to burn could contain toxic asbestos, which again, becomes lethal when broken down and inhaled. For example, in the UK last year, a group of young people unknowingly built a bonfire using asbestos-laden roofing sheets. Rather than risking your health, keep to using organic materials such as sticks or paper.

PROTECT YOURSELF

Your greatest form of protection this summer is knowledge. Educating yourself and your family on the dangers of asbestos exposure and spreading awareness is your greatest tool at reducing your risk. For many, however, taking these precautions and becoming aware is, tragically, no longer an option. However, there are ways you can help to lessen and prevent further pain for the individuals and families affected. The FACT Act, allegedly intended to promote transparency and prevent fraudulent asbestos claims, in reality invades the privacy of victims and their families, while the companies that victimized them in the first place are left untouched. Ultimately, the FACT Act protects asbestos companies while further victimizing those already suffering. Help support those who have suffered from asbestos by signing our petition. Together, we can help ensure everyone has the safest summer possible and prevent the furthered suffering of asbestos victims.”

If you or anyone you know has been diagnosed with Mesothelioma, consider connecting with these organizations dedicated to assisting mesothelioma victims and their families.  These organizations can help you find the best doctors, treatments and information about mesothelioma.

The Mesothelioma Cancer Alliance

The Mesothelioma Center

Mesthelioma HELP

Mesthelioma.Net

MesoCare

Mesothelioma Survivors

FREE Running Program for Cancer Survivors in MD, DC, VA, NY & Chicago

Andy & Alan 2004 Bay Bridge 10K

Andy & Alan @ Rockville Rotary Twilighter 8K Runfest 1992

 

Pictured above is my husband Alan (on the right) with his childhood friend Andy.  Since this picture was taken, Andy has run more than 30 marathons, completed 13 triathlons and has become a certified running coach.  Despite all these accomplishments, Andy always made time to go for a run or walk with Alan, even after he was diagnosed with cancer.

 

It was no surprise to me that Andy connected with The Ulman Cancer Fund’s CANCER to 5K Training Program - a FREE 12-week training program designed to introduce or reintroduce cancer survivors to training for and completing a 5K road race.  Amazing, right?!

ABOUT The CANCER to 5K Training Program:

Research has now shown that exercise is especially important for cancer survivors both in and out of active treatment.  Regular exercise not only improves mood, boosts self-confidence and reduces fatigue, but there is loads of evidence suggesting that higher levels of physical activity can help keep the cancer from recurring.

 

The Cancer to 5K Training Program is a progressive run/walk program designed to get cancer survivors to the 5K finish-line happy, healthy and injury-free.  

*  Who can join?  Cancer to 5K is open to any cancer survivor regardless of age, location, treatment status or fitness level.  Survivors who have completed treatment as well as survivors who are currently undergoing treatment can participate.

*  Where is training held?  If you live in the following areas, certified running coaches and experienced volunteer runners (aka “Sherpas”) will help train you in a small group setting.  Each 12-week session is limited to 10 participants.  Click HERE for exact locations in:

      • Washington DC/Northern Virginia
      • Montgomery County Maryland
      • Howard County, Maryland
      • Baltimore, Maryland
      • New York, NY
      • Chicago, IL.

* What if you live elsewhere?  If you live outside the current group training areas, you can still participate with The CANCER to 5K “At Home” Training Program.  As a Cancer to 5K “At Home” participant, you will receive one-on-one coaching with a Cancer to 5K coach. Workouts will be sent to you via email, and you will have access to your coach via email and phone.

Registration for the fall training season is now OPEN!  
Group workouts will begin in August 2014.
“At-Home” participants can begin training anytime.

 

For more information, contact Program Manager Laura Scruggs via email at laura@ulmanfund.org  or via 410.964.0202 x108.  

Please note:  A medical waiver must be signed by the participant’s current primary care physician to ensure that training for a 5K won’t negatively impact treatment or recovery.

 

Financial Assistance from Walk In My Shoes Cancer Foundation

 

 

If you’ve been diagnosed with cancer and are having a hard time making ends meet, check out the Walk In My Shoes Foundation.

Walk In My Shoes Foundation assists cancer patients with paying rent, mortgages, utility bills, medication, purchasing gas cards, buying groceries, etc.  To qualify for assistance, which is based on availability, the following guidelines have been set:

  • Only patients undergoing cancer treatment are eligible for assistance.
  • Only bills in patient’s name are eligible for payment.
  • Maximum assistance is $500.00 per patient per calendar year.
  • First come first serve basis.
  • No income guidelines.
  • Men, women, children are welcome to apply regardless of type of cancer.
  • Cash will not be disbursed.

To apply, please complete the form on the Walk In My Shoes Foundation CONTACT US page or email them directly at info@walkinmyshoesfoundation.com.  Someone should contact you within 48 hours.

The 4 Stages of Mesothelioma & Their Treatment Options

doctors Meet GUEST BLOGGER Michelle Whitmer.  Michelle has been a medical writer and editor for The Mesothelioma Center since 2008. Focused on the benefits of natural and holistic medicine for cancer patients, Michelle is a certified yoga instructor and earned her B.A. in Environmental Studies from Rollins College in Florida.

Accurately diagnosing a mesothelioma patient’s stage of cancer development is essential to getting appropriate treatment. The stages of mesothelioma are determined by the degree of tumor growth and spread. Stage I represents minimal tumor growth and stage IV indicates extensive tumor growth and spread.

Diagnosing the correct mesothelioma stage is challenging, but crucial to providing effective treatment recommendations. Unless your first opinion came from a mesothelioma expert, most people diagnosed with mesothelioma should seek a second opinion from one of the nation’s specialists. Because the cancer is relatively rare, few oncologists have experience diagnosing and treating mesothelioma. Seeking the opinion of a mesothelioma specialist could lead to better treatment.

For example, pleural mesothelioma specialist Dr. David Sugarbaker pioneered one of the most effective surgeries for the cancer, the extrapleural pneumonectomy. Patients with early-stage mesothelioma often qualify for his aggressive treatment approach that may significantly extend survival.

The same goes for people with peritoneal mesothelioma, which develops in the lining of the abdominal cavity. Specialist Dr. Paul Sugarbaker pioneered the most effective treatment for peritoneal mesothelioma, which is cytoreductive surgery with heated chemotherapy that is circulated throughout the abdominal cavity rather than systemically throughout the whole body. The treatment approach significantly improved survival rates for the cancer.

Diagnosing Mesothelioma

Mesothelioma is a challenging cancer to diagnose. There’s no officially adopted standard protocol for diagnosing mesothelioma, so patients will have different experiences. However, certain diagnostic tools are universally used to reach a mesothelioma diagnosis, such as imaging scans and biopsies.

In many cases, the first imaging scan patients receive is an X-ray, which is followed with more scans if anything unusual is seen in the X-ray. More detailed imaging scans like CT, PET and MRI come next. These scans help provide a clearer indication of how far the cancer may have spread.

To confirm a mesothelioma diagnosis, a biopsy is necessary. A thoracoscopy is a common biopsy for pleural mesothelioma that involves the use of a camera-tipped tube to collect a tumor sample. A mediastinoscopy might also be used to determine if the cancer has spread to the mediastinal lymph nodes, which are located between the lungs in the center of the chest. Spread to the lymph nodes is an indication of stage III cancer.

Treatment for Mesothelioma by Stage

Treatment recommendations are made based upon a patient’s stage. Early-stage tumors respond best to surgery, while stage IV mesothelioma has spread too far for surgery to be effective. Chemotherapy and radiation therapy may be used at any stage, except when a person’s general health is too poor to withstand the side effects.

Most people with mesothelioma receive multimodal therapy, which is the combination of two or more cancer treatments. The most effective combination for mesothelioma to date is surgery, chemotherapy and radiation therapy. This approach is most effective for stage I patients, but stage II and III patients often qualify for the aggressive approach with life-extending results. Stage IV patients may receive a combination of chemotherapy and radiation therapy to relieve symptoms and extend survival.

Stage I Treatment

Because tumor growth is minimal at stage I, surgery is highly recommended to remove as much cancerous tissue as possible. There are two surgeries patients may qualify for, a pleurectomy/decortication (P/D) and an extrapleural pneumonectomy (EPP). An EPP removes one lung while a P/D keeps the lung intact and only removes the lining of the lung.

Chemotherapy with the drugs cisplatin and Alimta is commonly administered after surgery in stage I patients. Radiation therapy is used after surgery to prevent local recurrence, though some centers are having improved success administering radiation prior to surgery to shrink tumors.

Stage II Treatment

Stage II surgery for pleural mesothelioma is usually an EPP. A P/D surgery wouldn’t be as effective since the cancer has spread to the lung in stage II. Following recovery from surgery, chemotherapy is recommended to kill remaining cancer cells the surgery couldn’t remove. Radiation therapy is then used to prevent recurrence, especially along surgery incisions (which is a common place for the cancer to recur).

Stage III Treatment

Certain patients in good health with stage III mesothelioma can qualify for an EPP. The surgery is extensive, so the person must be in adequate physical health to undergo the surgery. Chemotherapy and radiation therapy are given to destroy lingering cancer cells. If the cancer returns, second-line chemotherapy with other drugs, such as gemcitabine and vinorelbine, are recommended.

Stage IV Treatment

Stage IV tumors have grown too much and have spread too far for an EPP surgery to remove all the cancer. However, less aggressive surgeries might be recommended to otherwise healthy patients to reduce tumor size, which can help to relieve pain and improve breathing.

Chemotherapy and radiation therapy can be used to shrink tumors, which can help to relieve pain and improve breathing as well. They might also help to prolong life expectancy by several months.

Other therapies are given to alleviate symptoms, such as medication for pain, pulmonary rehabilitation to improve breathing and occupational therapy to reduce discomfort.

Because the cancer rarely causes symptoms in the early stages, the majority of mesothelioma patients are diagnosed in stage III or IV. Aggressive treatment is most effective at early stages, which stresses the importance of annual physical checkups for anyone who may have been exposed to asbestos in the past.

Sources:

Guidelines for the diagnosis and treatment of malignant pleural mesothelioma. 

Malignant mesothelioma: Review.

Malignant pleural mesothelioma: Update on treatment options with a focus on novel therapies. 

 

Personalizing YOUR Cancer Treatment (part 4): Do you know your cancer biomarkers?

Personalized-Medicine

In the near future, instead of saying, “I have breast cancer,” a patient will say something like , “I have a HER2-positive carcinoma with a KRAS mutation.”  Cancer will be defined by it’s own unique molecular profile and biomarkers rather than the body part where it originated.

To learn more about the dozens of biomarkers already being used to guide cancer treatment, check out the table below. Please note: there are thousands of known biomarkers without currently known effectiveness or relevance to cancer care. This table only represents the biomarkers that are currently known to be significant in informing cancer care today.*

Biomarker About Cancers that may benefit from testing Treatments associated with response or lack of response/resistance*
ALK anaplastic lymphoma kinase, an enzyme that can form a oncogenic fusion gene with EML4 lung (non-small cell), lymphoma (anaplastic large-cell), nervous system (familial neuroblastoma) crizotinib (Xalkori®), pemetrexed (Alimta®)
AR androgen receptor, part of the nuclear hormone receptor superfamily, active in cell signaling and therefore cell multiplication and growth prostate, breast, ovarian, bladder, lung (non-small cell) bicalutamide (Casodex®), flutamide (Eulexin®), goserelin (Zoladex®), leuprolide (Lupron®), abarelix (Plenaxis®), gonadorelin (Factrel®)
BRAF also know as v-raf murine sarcoma viral oncogene homolog B1, a proto-oncogene in the RAF/MIL family of molecules active in MAP/ERK cell signaling, promotes cell multiplication and growth colon, skin (melanoma), lung (adenocarcinoma), thyroid (papillary thyroid carcinoma), nervous system (pleomorphic xanthoastrocytomas with and without anaplasia) cetuximab (Erbitux®), panitumumab (Vectibix®), vemurafenib (Zelboraf®)
BRCA1 a so-called “breast cancer gene”, its expression in many cancers can indicate potential response to certain types of therapies lung, ovarian cisplatin (Platinol®)
c-Kit cytokine receptor also know as CD117, a proto-oncogene that interacts with cell growth factors, plays a roll in cell survival, multiplication and differentiation GIST (gastrointestinal stromal tumor), skin (melanoma), blood (acute myelogenous leukemia) imatinib (Gleevec®), sorafenib (Nexavar®), sunitinib (Sutent®)
c-MET also known as MET (mesenchymal epithelial transition factor) or HGFR (hepatocyte growth factor receptor), a proto-oncogene active in cell signaling, promotes cancer cell growth and multiplication lung (non-small cell), ovarian erlotinib (Tarceva®), gefitinib (Iressa®)
COX-2 cyclooxygenase-2, also known as protaglandin-endoperoxide synthase-2 (PTGS2), an enzyme important to creation of prostaglandins, which are messenger molecules that play a role in many cancers lung (non-small cell) celecoxib (Celebrex®)
EGFR epidermal growth factor receptor, also known as ErbB-1 or HER1, a receptor tyrosine kinase active in cell signaling, promotes cell growth and multiplication lung (non-small cell) cetuximab (Erbitux®), erlotinib (Tarceva®), gefitinib (Iressa®), panitumumab (Vectibix®)
EGFR secondary mutation (T790 M) a mutation of the EGFR gene associated with acquired resistance to certain treatments lung (non-small cell), colorectal, head and neck resistance to erlotinib (Tarceva®), gefitinib (Iressa®)
ER estrogen receptor, part of the nuclear hormone family of intracellular receptors, active in cell multiplication breast, ovarian, female genital tract cancer anastrazole (Arimidex®), exemestane (Aromasin®), letrozole (Femara®), tamoxifen (Nolvadex®), megestrol acetate (Megace®, Megace® ES), fulvestrant (Faslodex®), toremifene (Fareston®), medroxyprogesterone, (Provera®, Amen®, Curretab®, Cycrin®), goserelin (Zoladex®), leuprolide (Eligard®, Lupron®, Viadur®)
ERCC1 excision repair cross-complementation group 1, an enzyme active in DNA repair and therefore a sign of resistance to treatments that work by disrupting tumor DNA lung (non-small cell and small cell), gastric, ovarian, colorectal, bladder resistance to cisplatin (Platinol®), carboplatin (Paraplatin®), oxaliplatin (Eloxatin®)
HER2 human epidermal growth factor receptor 2, also known as HER2/neu or ErbB-2, a receptor tyrosine kinase active in cell signaling, promotes cell growth and multiplication breast, gastroesophageal, gastric, ovarian, colorectal lapatinib (Tykerb®), trastuzumab (Herceptin®), doxorubicin (Adriamycin®, Rubex®), liposomal doxorubicin (Caelyx®, Myocet®), epirubicin (Ellence®)
KRAS proto-oncogene of the Kirsten murine sarcoma virus, active in cell signaling in the EGFR pathway, promotes cell growth and multiplication lung (non-small cell), colon, pancreatic cetuximab (Erbitux®), erlotinib (Tarceva®), gefitinib (Iressa®), panitumumab (Vectibix®)
MGMT O-6-methylguanine-DNA methyltransferase is a gene that encodes a DNA repair enzyme, loss of MGMT may play a role in cancer formation, MGMT can also interfere with treatments that work by disrupting tumor DNA breast, lung (non-small cell), esophageal, brain (glioblastoma multiforme, oligodendrogliomas), skin (melanoma), pituitary gland (carcinoma) lack of response to temozolomide (Temodar®)
MRP1 multidrug resistance-associated protein 1, an ATP-dependent transmembrane drug efflux pump associated with resistance to many drugs breast, lymphoma, head and neck lack of response to anthracyclines such as doxorubicin (Adrimycin®), vinca alkaloids, and methotrexate (Trexall®)
PGP p-glycoprotein, also known as P-gp, an ATP-dependent transmembrane drug efflux pump associated with acquired resistance to many drugs breast, ovarian, lymphoma, head and neck lack of response to anthracylines such as doxorubicin (Adriamycin®), epirubicin (Ellence®) and liposomal-doxorubicin (Doxil®), and other drugs such as paclitaxel (Taxol®), docetaxel (Taxotere®), vinblastine (Velban®), vincristine (Oncovin®), vinorelbine (Navelbine®)
PIK3CA a specific mutation within the PI3 (phosphoinositide 3) kinase pathway or a gene copy number variation, aberrations along the PI3K pathway are associated with many cancers colorectal, brain (glioblastoma), gastric, breast, lung, ovarian lapatinib (Tykerb®); resistance to cetuximab (Erbitux®), panitumumab (Vectibix); decreased response to trastuzumab (Herceptin®)
PR progesterone receptor, also called PGR, part of the nuclear hormone family of intracellular receptors, active in cell multiplication breast, ovarian, female genital tract cancer letrozole (Femara®), tamoxifen (Nolvadex®), fulvestrant (Faslodex®), toremifene (Fareston®), exemestane (Aromasin®), anastrozole (Arimidex®), goserelin (Zoladex®), gonadorelin (Factrel®), leuprolide (Eligard®, Lupron®, Viadur®), medroxyprogesterone (Provera®, Amen®, Curretab®, Cycrin®), megestrol acetate (Megace®, Megace® ES)
PTEN phosphatase and tensin homolog, a tumor suppressor active in EGFR, HER2 and AKT cell signaling pathways breast, colon, lung (non-small cell), brain (glioblastoma), head and neck low expression associated with lack of response to cetuximab (Erbitux®), gefitinib (Iressa®), trastuzumab (Herceptin®), panitumumab (Vectibix®), erlotinib (Tarceva®)
RRM1 ribonucleotide reductase subunit M1, an enzyme required for DNA synthesis from RNA and therefore can interfere with treatments that work by disrupting RNA activity lung (non-small cell), pancreatic high expression associated with lack of response to gemcitabine (Gemzar®), hydroxyurea (Hydrea®, Droxia®)
SPARC secreted protein acidic rich in cysteine, a protein active in tumor growth and spreading skin (melanoma), breast, gastric, pancreatic, head and neck albumin-bound paclitaxel/nab-paclitaxel (Abraxane®)
TLE3 a member of the transducin-like enhancer of split family of proteins, implicated in creation of tumors breast, ovarian taxane therapy such as paclitaxel (Taxol®), docetaxel (Taxotere ®)
TOPO2A topoisomerase IIA, an enzyme active in DNA synthesis and repair breast, colon, ovarian, lung (small cell) doxorubicin (Adriamycin®), epirubicin (Ellence®, Pharmorubucin®), liposomal doxorubicin (Caelyx®, Myocet®)
TS thymidylate synthetase, an enzyme active in DNA synthesis and repair, can be inhibited by certain compounds breast, colon, gastric, head and neck, liver, pancreatic, lung (non-small cell) lack of response to 5-fluorouracil (Adrucil®), cytarabine (Cytosar-U®), pemetrexed (Alimta®)
TUBB3 Class III -tubulin, protein found in microtubules which are important cell structures ovarian, lung (non-small cell) taxanes such as paclitaxel (Taxol®), docetaxel (Taxotere ®), vinca alkaloids such as vinorelbine (Navelbine®)

* Biomarker status (overexpressed, underexpressed, positive or negative for specific mutations, etc.) determines whether that biomarker is associated with response, lack of response or resistance to each treatment. Treatment associations are from published, peer-reviewed medical literature. Citations available upon request. Only your doctor can decide which treatments are appropriate for you.

**Got questions about YOUR biomarkers, e-mail PatientNavigator@carisls.com.  A Patient Navigator who is well versed in molecular profiling and biomarkers will answer your questions.  (this is a FREE service provided by Caris Life Sciences.) 

*** Source:  MyCancer.com (an educational resource sponsored by Caris Life Sciences®) is a fantastic website for cancer patients and their caregivers that provides information about personalizing your cancer treatment using molecular profiling and cancer biomarkers.

If You’ve Been Touched By Breast Cancer & Are Planning A Wedding, Read On…

Image credit:  123RF Stock Photo

Image credit: 123RF Stock Photo

 

It’s that time of year again when The Wedding Pink presents one couple whose lives have been recently touched by breast cancer with a FREE dream wedding, valued between $30,000- $40,000.  OMG! So amazing!!

 

Founder Cheryl Ungar is a 23-year breast cancer survivor and a wedding photographer.  She has put together an extraordinary team of some of Colorado’s top wedding vendors — all of whom have generously agreed to donate their services and products to ensure The Wedding Pink is a spectacular event for one very special couple.

 

Here’s the dealio (as my daughter always says)…  If your life has been recently touched by breast cancer (fyi, the experience is not limited to the bride, but could be with the bride or groom’s extended family member) AND are engaged or soon-to-be-engaged, you could be the lucky winner of this fairy tale wedding.

 

This year’s Wedding Pink will will take place May 15, 2015 in Denver, Colorado.  Applications are open to ANY legal resident of the US regardless of what state they live in.  Submissions will be open from August 1 – August 10.  The winning couple will be selected in early September 2014.  There are no income qualifications.  Winners will be chosen by a panel of judges.  To learn more about the submission criteria, click HERE.

Wishing you all a lifetime of health, love & happiness together….

Soy for Lung Cancer: 2 Tofu Recipes to Potentially Help Inhibit Malignant Growth

Soy

Meet GUEST BLOGGER Faith Franz.  Faith is a writer for The Mesothelioma Center, an organization that provides support and resources for people and families with this rare disease.  Faith also likes to spread the word about the benefits of alternative medicine.

Tofu –it’s what’s for dinner. (If you’re trying to naturally prevent lung cancer growth, that is.)

In a recent 2013 article, researchers from the University of Arkansas found that soybeans with a high oleic acid content could inhibit the growth of several cancers by up to 70 percent. Among the malignancies:

  • Lung cancer (growth reduced by 68%)*
  • Colon cancer (growth reduced  by 73%)*
  • Liver cancer (growth reduced by 70%)*

This was certainly not the first study to identify anti-cancer benefits in soy. Other studies exploring the correlation between soy and lung cancer date back to 1985, and one published this month indicates high-soy diets may correlate with longer cancer survival rates. (That study found that women who ate more than 21 grams of soy protein per day were more likely to reach five-year survival after a lung cancer diagnosis.)*

However, this study was the first note these specific bioactive benefits in three individual soy protein isolates. The University of Arkansas was also the first organization to identify two of the three high-oleic acid soybean varieties, as part of an ongoing soybean breeding program.

Oleic acid – the main fat component in the much-acclaimed olive oil – is also associated with breast cancer inhibition.

Lab workers tested each of the soy isolates against cell lines from lung, colon and liver cancer samples. They found that growth for each type of cancer significantly slowed after exposure to the soy isolates, and that higher doses produced greater results.

Several other food-derived compounds offer lung cancer inhibitory benefits. These include reservatrol, an antioxidant in red wine, and curcumin, the main component of the Indian herb turmeric.

Tofu, Two Ways

Tofu has a bad reputation as a bland, oddly textured food. But when prepared correctly, nothing can be further from the truth.

Just like you wouldn’t serve raw, unseasoned meat, you can’t serve raw, unseasoned tofu. It needs a zesty marinade and some added fat to taste its best.  It also needs to be pressed to remove excess water; without pressing, it’ll be soggy, no matter how long you cook it.

You’ll need to be sure to purchase tofu that’s certified organic or made from non-genetically modified soybeans. (The health effects of genetically modified foods are not completely known, but what we do know suggests that they’re not ideal for health). While the study uses soybeans that are bred to have higher-than-average oleic acid concentrations, there are several natural ways to breed non-modified high-oleic acid soybeans.

The following two soy-based recipes are full of plant-based protein (more than 15 grams per serving):

Crispy Baked Garlic Tofu (serves one)

Ingredients:

1/3 package organic tofu

1 whole egg

1/3 cup Panko breadcrumbs

1 tablespoon garlic paste

1 teaspoon onion powder

½ teaspoon cayenne pepper

½ teaspoon thyme

Salt and pepper, to taste

Directions:

-  Thinly slice tofu; press between paper towels for five minutes to remove moisture.

- Preheat oven to 400 degrees.

- In one bowl, whip together the egg and garlic paste. In another bowl, blend together the Panko, onion, cayenne, thyme, salt and pepper.

- Dip each tofu slice into the egg mixture, then roll in Panko coating. Arrange on a greased cookie sheet, then bake 10-13 minutes until crispy). Serve warm.

Easy Tofu Stir Fry (serves one)

Ingredients:

1/3 package organic tofu

1 floret fresh broccoli

½ cup sliced carrots

½ onion

1 can baby corn or water chestnuts

¼ cup organic soybean oil

Teriyaki sauce and soy sauce, to taste

1 serving brown rice or soba noodles

Directions:

-  Cut tofu into cubes; press between paper towels for five minutes to remove moisture.

-Cook rice/noodles according to package.

- Add vegetables, oil, teriyaki sauce and soy sauce to a wok (or skillet). Sautee for 5 minutes; add tofu cubes. Sautee another 4-6 minutes, flipping the cubes so each side gets firm and brown.

If desired, add another dash of teriyaki or soy; serve over the rice or soba noodles.

Do you cook with soy? If so, what are your favorite tofu or tempeh recipes? If you try out either of these recipes, let us know your thoughts in the comments.

 

*Sources:

Seaman, A. M. (26 March 2013). Soy tied to better lung cancer survival among women. Reuters. 

Rayaprolu, S. J., Hettiarachchy, N. S., Chen, P., Kannan, A., & Mauromostakos A. (2013). Peptides derived from high oleic acid soybean meal inhibit colon, liver and lung cancer cell growth. Food Research International; 50 (1).